The compound's ability to restore tissue homeostasis and reverse age-related functional decline in animal models provides direct evidence for the role of senescent cells in aging processes, while its applications in cancer research offer insights into senescence mechanisms in disease progression and administration resistance
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What was the main outcome
As fat mass decreases due to weight loss, the secretion of adipokines changes, which can impact hormone levels involved in the menstrual cycle, such as estrogen and progesterone
Klein and Hobai 2023
Notably, IGF-1 promotes neurogenesis in the hippocampus, and reduced IGF-1 levels have been linked to depressive-like behaviors in animal models [97, 98]