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The compound's ability to restore tissue homeostasis and reverse age-related functional decline in animal models provides direct evidence for the role of senescent cells in aging processes, while its applications in cancer research offer insights into senescence mechanisms in disease progression and administration resistance

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Notably, IGF-1 promotes neurogenesis in the hippocampus, and reduced IGF-1 levels have been linked to depressive-like behaviors in animal models [97, 98]

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